No. Absolutely nothing like Weeds. The show is brilliant and a lot of the main focus of the story is how the main character is dealing with his probable death. If memory serves, the first season got cut short because of the writers strike and I'm so glad it's back on.
Some of the draw is how he uses his chemistry education to get himself out of certain situations. I was worried it was going to become a huge gimmick but they throw just enough of it in there to show you that he's clever, not to make it a "Here's the chemistry trick of the week!" show.
Also this show is totally bad ass at times. I was planning on shaving my head for the summer last year but when he did it in the show I pretty much did it that night. Dorky, I know.
To add, I did not also grow a mustache.