Nobody wants to talk about this?! lol.
Yeah, I work with a lot of British people, and they are all very disappointed.
In the end though, as far as UK/Canadian relations go, this is probably a big plus for Canada.
I would guess the real story is the fact that all of Scotland voted to remain (and Northern Ireland did too), and Scotland independence from the UK has been another massive issue. People who donated millions against Scotish indipendence have now completely reversed their support, and now are pro-independence: JK Rowling for instance.
England took EU away from Scotland. That was a major selling point for the pro-UK side of the argument: they weren't fully ruled by England due to their membership with the EU - leaving the UK would also mean leaving the UK's special benefits. Now that's no longer a factor.
In short:
Scotland lost EU against their wishes.
England is the culprit who took EU from them.
Scotland has justification for a new referendum.
Scotland, will likely be voting to leave the UK in the near future.
Other negative effects for the UK,
Cameron resigned.
The pound collapsed - biggest plunge in history, and it went from a 20 year high to a 30 year low in one day. The UK economy officially slipped to third in Europe from second, now behind France.